Medical Device

🧠 Neuro-Interventional Guidewires & Catheters

Extremely slender wire (OD 0.2-1.0mm) with a shaped distal tip, tapered core, and PTFE/hydrophilic coating

3 Processes

What is Neuro-Interventional Guidewires & Catheters?

🧠 Neuro-Interventional Guidewires & Catheters represents a complete system of precision titanium components engineered for Medical Device applications. Extremely slender wire (OD 0.2-1.0mm) with a shaped distal tip, tapered core, and PTFE/hydrophilic coating The system integrates 0 distinct component types manufactured through 3 specialized processes.

Engineering & Design Principles

Material: Nitinol core wire provides the superelasticity needed to navigate tortuous cerebral vasculature without permanent deformation. Steel guidewires kink permanently when bent beyond 90 degrees.

Form: Nitinol wire is precision-drawn to final diameter. Core grinding creates a tapered distal segment for flexibility. Shape-setting heat treatment forms the custom distal tip geometry.

Standards & Material Specifications

Standards: ASTM F2063 Nitinol core wire, superelastic, 100% dimensional + torque response tested, sterile

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Engineering Solution Blueprint

Cardiovascular Stents, TAVI Frames & Neuro-Interventional Devices

Medical Device

1 Part Feature Analysis

Laser-cut tube (stent) with expandable lattice cells, self-expanding Nitinol TAVI frame with barbed anchoring and sealing skirt interface, neurovascular guidewire core with precision-ground tapered distal section

  • ⚠️ Fatigue fracture of stent struts under cyclic arterial loading (400M+ cycles/year)
  • ⚠️ Restenosis from excessive vascular injury during deployment
  • ⚠️ Stent thrombosis from incomplete endothelialization
  • ⚠️ MRI compatibility for post-operative imaging surveillance
  • ⚠️ Guidewire tip kinking during navigation of tortuous cerebral vasculature

2 Material Selection Rationale

Nitinol (Ni-Ti Shape Memory Alloy) — Superelastic, shape memory effect, high damping

Nitinol (Ni-Ti Shape Memory Alloy, ASTM F2063) is the standard for self-expanding stents and TAVI frames — superelastic plateau strain >8% for vessel conformability and crush recovery. Grade 23 ELI for balloon-expandable stent platforms requiring high radial strength with low strut thickness (65-80um). Nitinol guidewire core for neuro-interventional kink resistance.

3 Form Selection Rationale

Seamless Tube — for fluid systems, heat exchangers

Seamless Nitinol tube (OD 1.5-8mm) for laser-cut stent and TAVI frame manufacturing. Centerless-ground wire for guidewire cores. Tube wall thickness 0.15-0.5mm for stents.

4 Manufacturing Process & Services

Core Processes:

Vacuum arc melting (VAR) of Nitinol ingot (precise Ni:Ti ratio)Laser tube cutting of stent lattice patternShape setting heat treatment in argon atmosphereElectrochemical polishing of strut surfacesCrimping + loading onto delivery balloon/catheter

Toll Processing Services:

Scanning electron microscopy (SEM) of strut qualityCrimped profile measurementExpansion test (balloon or self-expanding)Fatigue testing (accelerated 10-year simulation)Sterilization validation

Process Pitfalls:

  • ⚠️ Nitinol transformation temperature (Af) must be tuned to +-2C for body-temperature superelasticity — off-spec Af causes incomplete stent expansion
  • ⚠️ Stent strut surface must be free of micro-cracks >5um — laser dross must be removed by electrochemical polishing without over-etching

5 Procurement Specifications

ASTM F2063 Nitinol / ASTM F136 Ti-6Al-4V ELI, 100% SEM of cut quality + expansion tested per lot, ethylene oxide sterilized

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Manufacturing Process Flow

1
Centerless grinding of core taper

5-axis CNC milling centers provide simultaneous multi-axis interpolation for complex titanium components. The ability to tilt the tool relative to the

2
Shape-setting of distal tip

Professional manufacturing process for titanium components. Shape-setting of the distal tip is performed by certified technicians following approved p

3
Wire drawing & straightening

Press brake forming of titanium sheet uses CNC-controlled backgauges and variable-radius tooling to produce precision bends. Titanium's high springbac

Components in This System

Frequently Asked Questions

What titanium grades are used in Neuro-Interventional Guidewires & Catheters systems?
Neuro-Interventional Guidewires & Catheters components are manufactured from titanium grades selected for their specific functional requirements, including Grade 2, Grade 5 (Ti-6Al-4V), and Grade 23 ELI as applicable.
What manufacturing processes are used for Neuro-Interventional Guidewires & Catheters?
Neuro-Interventional Guidewires & Catheters components are manufactured using processes selected for each component's specific geometry, tolerance, and volume requirements.
What quality standards apply to Neuro-Interventional Guidewires & Catheters components?
All Neuro-Interventional Guidewires & Catheters components are manufactured under ISO 9001:2015 and AS9100D certified quality management systems.
What industries use Neuro-Interventional Guidewires & Catheters?
Neuro-Interventional Guidewires & Catheters systems serve the Medical Device industry, with components engineered to meet sector-specific regulatory and performance standards.
Can you provide DFM feedback for Neuro-Interventional Guidewires & Catheters designs?
Yes. Our engineering team provides free Design for Manufacturability (DFM) analysis for Neuro-Interventional Guidewires & Catheters projects. Upload your CAD file (STEP, DXF, or DWG format) and our team will review your design within 24 hours.

Engineering Trends

  • ▸ Process: Wire drawing & straightening
  • ▸ Process: Centerless grinding of core taper
  • ▸ Process: Shape-setting of distal tip

Related Manufacturing Capabilities

These specialized processes support Neuro-Interventional Guidewires & Catheters component manufacturing.

Centerless grinding of core taper Shape-setting of distal tip Wire drawing & straightening
About Boze Titanium Manufacturing Center

One Metal. One Focus. Infinite Precision.

Founded in 2011 in Baoji's Titanium Valley, BOZE Metal is dedicated exclusively to titanium — from raw material to precision engineering. AS9100D, ISO 13485 & ISO 9001 certified with 500+ clients across Aerospace, Medical & Motorsport industries, we deliver end-to-end precision titanium CNC machining with full material traceability from source to component.

Boze Titanium Manufacturing Center is operated by Baoji Boze Metal Products Co., Ltd.

AS9100D ISO 13485 ISO 9001 500+ Clients 15+ Years OEM/ODM
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